Absci enables our partners to explore the broadest possible solution space faster than conventional methods. Our multi-parameter optimization approach tunes affinity, specificity, manufacturability, and safety all at once. Our Integrated Drug Creation™ platform gives drug makers new potential:
Starting with your envisioned drug format and target antigen, Absci generates a library of relevant sequence variants to establish the target specificity, creating novel lead drug candidates with desirable attributes, including manufacturability and Naturalness.
With multiparametric AI lead optimization, we can simultaneously evaluate variants for improved target affinity, manufacturability, and other pharmacologic characteristics, bringing truly optimal lead candidates to the clinic.
We reconstruct prevalent immune-response molecules such as antibodies from disease tissue and identify their corresponding antigens, offering new therapeutic targets, as well as the cognate binding partners, for further potential validation and optimization.
With genetic engineering, Absci incorporates a site-specific non-standard amino acid to generate Bionic Proteins™ with chemical handles that can be used for post-translational modifications including glycosylation, PEGylation, and ADC-payload conjugation, as well as novel branched proteins and chemical conjugates.
How can our Integrated Drug Creation™ platform help you go from drug discovery to drug creation?