Absci Announces Closing of Public Offering and Full Exercise of Underwriters’ Option to Purchase Additional Shares | Absci Press Releases Archives - Absci

Vancouver, WA, July 26, 2021 — Absci Corporation (“Absci”), the synthetic biology company unlocking the potential of proteins as next-generation therapeutics, today announced the closing of its initial public offering of 14,375,000 shares of common stock, including the exercise in full by the underwriters of their option to purchase up to an additional 1,875,000 shares of common stock, at a public offering price of $16.00 per share. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Absci were $230.0 million. Absci’s common stock began trading on the Nasdaq Global Select Market on July 22, 2021, under the ticker symbol “ABSI.” All shares in the offering were offered by Absci.

J.P. Morgan, Credit Suisse, BofA Securities, Cowen, and Stifel acted as lead book-running managers for the offering.

A registration statement relating to the shares being sold in this offering was declared effective by the Securities and Exchange Commission on July 21, 2021. The offering is being made only by means of a prospectus, copies of which may be obtained, when available, from: J.P. Morgan Securities LLC,, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (866) 803-9204, or by email at [email protected]; Credit Suisse Securities (USA) LLC, Attn: Prospectus Department, 6933 Louis Stephens Drive, Morrisville, NC 27560, by telephone at (800) 221-1037, or by email at [email protected]; BofA Securities, Attention: Prospectus Department, NC1-004-03-43, 200 North College Street, 3rd Floor, Charlotte, NC 28255-0001, or by e-mail at [email protected]; Cowen and Company LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY,11717, Attn: Prospectus Department, by email at [email protected] or by telephone at (833) 297-2926; or Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720, or by email at [email protected] Copies of the final prospectus related to the offering are available at www.sec.gov.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

About Absci

Absci is the AI-powered synthetic biology company unlocking the potential of proteins as the next generation of therapeutics. We built our Integrated Drug Creation™ Platform to accelerate discovery of novel biotherapeutic drug candidates and generation of the cell lines to manufacture them in a single efficient process. Biotech and pharma innovators partner with us to develop new protein-based drugs, including those that may be impossible to make with other technologies. Our goal is to enable the creation of better medicines by Translating Ideas into DrugsTM.

VANCOUVER, Wash., July 21, 2021 (GLOBE NEWSWIRE) — Absci Corporation (“Absci”), the synthetic biology company unlocking the potential of proteins as next-generation therapeutics, today announced the pricing of its initial public offering of 12,500,000 shares of common stock at a public offering price of $16.00 per share. All of the shares of common stock are being offered by Absci. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Absci, are expected to be $200.0 million, excluding any exercise of the underwriters’ option to purchase additional shares. Absci’s common stock is expected to begin trading on the Nasdaq Global Select Market on July 22, 2021, under the ticker symbol “ABSI.” The offering is expected to close on July 26, 2021, subject to the satisfaction of customary closing conditions. In addition, Absci has granted the underwriters a 30-day option to purchase up to an additional 1,875,000 shares of common stock at the initial public offering price, less the underwriting discounts and commissions.

J.P. Morgan, Credit Suisse, BofA Securities, Cowen, and Stifel are acting as lead book-running managers for the offering.

A registration statement relating to the shares being sold in this offering was declared effective by the Securities and Exchange Commission on July 21, 2021. The offering is being made only by means of a prospectus, copies of which may be obtained, when available, from: J.P. Morgan Securities LLC,, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (866) 803-9204, or by email at [email protected]; Credit Suisse Securities (USA) LLC, Attn: Prospectus Department, 6933 Louis Stephens Drive, Morrisville, NC 27560, by telephone at (800) 221-1037, or by email at [email protected]; BofA Securities, Attention: Prospectus Department, NC1-004-03-43, 200 North College Street, 3rd Floor, Charlotte, NC 28255-0001, or by e-mail at [email protected]; Cowen and Company LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY,11717, Attn: Prospectus Department, by email at [email protected] or by telephone at (833) 297-2926; or Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720, or by email at [email protected] Copies of the final prospectus, when available, related to the offering will be available at www.sec.gov.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

About Absci

Absci is the AI-powered synthetic biology company unlocking the potential of proteins as the next generation of therapeutics. We built our Integrated Drug Creation™ Platform to accelerate discovery of novel biotherapeutic drug candidates and generation of the cell lines to manufacture them in a single efficient process. Biotech and pharma innovators partner with us to develop new protein-based drugs, including those that may be impossible to make with other technologies. Our goal is to enable the creation of better medicines by Translating Ideas into Drugs™.

Biotechnology industry veterans Dr. Sarah Korman and Nikhil Goel to lead legal and business development teams

Vancouver, Wash., July 7, 2021 — Absci, the synthetic biology company unlocking the potential of proteins as next-generation therapeutics, today announced two strategic hires joining its executive team: Nikhil Goel as Chief Business Officer and Dr. Sarah Korman as General Counsel. These appointments come at a time of significant growth for Absci, as it scales its technology development programs and partnerships and integrates its recent acquisitions of Totient and Denovium.

“As we continue to innovate and expand our work with partners to create new next-generation proteins, Nikhil and Sarah are well-positioned to help us strategically grow our business,” said Sean McClain, founder and CEO of Absci. “Their extraordinary individual expertise, and combined experience building teams, executing transactions, and securing value around biotechnology innovations, will allow us to apply our technology platform more broadly, and enable the development of exciting new drug candidates.”

Dr. Korman joins Absci as General Counsel and will be responsible for leading the legal team that oversees business transactions, intellectual property strategy and patent estate expansion, compliance, corporate governance, and risk management. She has more than 15 years of strategic legal and intellectual property experience. Previously, she served as General Counsel and Corporate Secretary at NEUVOGEN, and before that at Amgen, where she was Head of Intellectual Property for Final Drug Products. Under her supervision, Amgen meaningfully expanded its patent estate to encompass multiple new combination products. She also held senior legal positions at Onyx Pharmaceuticals, where she managed intellectual property, transactional, and commercial matters and participated in the Amgen acquisition. Dr. Korman holds a Ph.D. in Materials Science & Engineering from The Pennsylvania State University and a J.D. from DePaul University College of Law. She is a National Science Foundation Fellow and an inventor on various patents directed to nano-enabled therapeutics and drug delivery. 

As Chief Business Officer, Mr. Goel will be responsible for overseeing the company’s business development and alliance management team focused on driving partnerships within the biotechnology and pharmaceutical industries. He brings nearly a decade of experience working with biotechnology companies as an investment banker, most recently as a Director in Credit Suisse’s Mergers and Acquisitions business, where he was responsible for sourcing and executing transactions. Prior to joining Credit Suisse, Mr. Goel spent more than three years at Barclays and Wells Fargo in their healthcare investment banking practices. While working as an investment banker, he successfully executed more than $150 billion in announced mergers and acquisitions. Mr. Goel holds an MBA from the Darden School of Business, University of Virginia, and a Masters in Computer Science from Georgia Institute of Technology. Together, Dr. Korman and Mr. Goel will help Absci continue to scale its business and pursue its goal of making the best medicines available to patients in need.

These new additions to the executive team come as Absci continues to build critical momentum.

About Absci

Absci is the AI-powered synthetic biology company unlocking the potential of proteins as the next generation of therapeutics. We built our Integrated Drug Creation™ Platform to accelerate discovery of novel biotherapeutic drug candidates and generation of the cell lines to manufacture them in a single efficient process. Biotech and pharma innovators partner with us to develop new protein-based drugs, including those that may be impossible to make with other technologies. Our goal is to enable the creation of better medicines by Translating Ideas into DrugsTM. For more information, please visit absci.com.

Contact:

[email protected]

VANCOUVER, Wash., June 30, 2021 /PRNewswire/ — Absci Corporation (“Absci”), the synthetic biology company unlocking the potential of proteins as next-generation therapeutics, announced today that it has filed a registration statement on Form S-1 with the U.S. Securities and Exchange Commission (“SEC”) relating to a proposed initial public offering of shares of its common stock. The number of shares to be offered and the price range for the proposed offering have not yet been determined. Absci has applied to list its common stock on The Nasdaq Global Market under the symbol ABSI. 

J.P. Morgan, Credit Suisse, BofA Securities, Cowen, and Stifel will act as joint book running managers for the proposed offering. 

A registration statement on Form S-1 relating to the proposed offering has been publicly filed with the SEC but has not yet become effective. These securities may not be sold, nor may offers to buy be accepted, prior to the time the registration statement becomes effective.

This press release does not constitute an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

The proposed offering will be made only by means of a prospectus. Once available, a copy of the preliminary prospectus related to the offering may be obtained by contacting: J.P. Morgan Securities LLC,, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (866) 803-9204, or by email at [email protected]; Credit Suisse Securities (USA) LLC, Attn: Prospectus Department, 6933 Louis Stephens Drive, Morrisville, NC 27560, by telephone at (800) 221-1037, or by email at [email protected]; BofA Securities, Attention: Prospectus Department, NC1-004-03-43, 200 North College Street, 3rd Floor, Charlotte, NC 28255-0001, or by e-mail at [email protected]; Cowen and Company LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY,11717, Attn: Prospectus Department, by email at [email protected] or by telephone at (833) 297-2926; or Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720, or by email at [email protected] 

About Absci
Absci is the AI-powered synthetic biology company unlocking the potential of proteins as the next generation of therapeutics. We built our Integrated Drug Creation™ Platform to accelerate discovery of novel biotherapeutic drug candidates and generation of the cell lines to manufacture them in a single efficient process. Biotech and pharma innovators partner with us to develop new protein-based drugs, including those that may be impossible to make with other technologies. Our goal is to enable the creation of better medicines by Translating Ideas into Drugs™. 

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Absci
101 East 6th St, Suite 300, Vancouver WA 98660

Vancouver, Wash., June 14, 2021 – AbSci, the synthetic biology company unlocking the potential of proteins as next-generation therapeutics, today announced the acquisition of Totient, a discovery company harnessing human immune responses to identify novel antibodies and their therapeutic targets. This acquisition adds antibody and target discovery technology to AbSci’s platform for therapeutic protein design and biomanufacturing optimization.

The development of comprehensive predictive models that encompass the interactions of key proteins related to immune responses in different disease states is an enormous opportunity for biologic drug development. Building on Totient’s ability to identify fully-human antibodies from patients who demonstrate differentiated immune responses, AbSci expects to generate a large collection of natural human antibodies and target antigens that it may leverage for therapeutic protein design as well as deep learning model training.

To date Totient has reconstructed more than 4,500 antibodies from over 50,000 patients and has de-orphaned a collection of promising antibodies by identifying and validating their target antigens. AbSci’s high-throughput single cell protein expression systems and assays offer a complementary platform for rapidly and systematically de-orphaning the computationally derived antibody sequences in Totient’s growing library.

The disease targets identified may be used in the discovery of new therapeutics, including those based on paired antibody sequences. Additionally, the data captured from billions of single cell experiments offer training sets for AbSci’s Denovium Engine™ deep learning models.

“Totient’s innovative work identifying disease-relevant molecules has exciting therapeutic potential,” commented Sean McClain, founder and CEO of AbSci. “We believe that the combination of the Totient technology with AbSci’s platform, including our Denovium AI, provides us the framework and data to enable in silico targeted drug design, and ultimately achieve our goals of making the best medicines available to patients in need.”

“Together, AbSci and Totient are much more than the sum of our parts, with clear opportunities for synergy of our platforms and technologies,” said Deniz Kural, PhD, co-founder and CEO of Totient. “Our computational biology technology allows us to identify thousands of new antibodies and other categories of proteins, and with AbSci, we look forward to scaling our target discovery capabilities to comprehensively de-orphan antibodies and validate new opportunities for drug development.”

Terms of the transaction are not being disclosed at this time.

About AbSci

AbSci is the AI-powered synthetic biology company unlocking the potential of proteins as the next generation of therapeutics. We built our Integrated Drug Creation™ Platform to accelerate discovery of novel biotherapeutic drug candidates and generation of the cell lines to manufacture them in a single efficient process. Biotech and pharma innovators partner with us to develop new protein-based drugs, including those that may be impossible to make with other technologies. Our goal is to enable the creation of better medicines by Translating Ideas into DrugsTM. For more information, please visit absci.com.

About Totient

Totient is enabling next generation cell therapies and other therapeutic modalities by building the largest library of human-derived antibodies to novel and known tissue-specific antigens. Totient reconstructs antibodies from patients experiencing exceptional immune responses. For more information, visit www.totient.bio.

Contact:
[email protected]

Round was co-led by Casdin Capital and Redmile Group
Fidelity Management & Research Company LLC, D1 Capital Partners, and Perceptive Advisors are among the new investors

VANCOUVER, Wash., March 23, 2021 /PRNewswire/ — AbSci, a pioneering synthetic biology company that unifies biologic drug discovery and development processes, today announced a $125 million crossover financing. The round was co-led by existing investors Casdin Capital and Redmile Group, with participation from new investors Fidelity Management and Research Company LLC, D1 Capital Partners, Perceptive Advisors, aMoon Edge, and Irving Investors, as well as other existing investors including ArrowMark Partners.

“We are thrilled to have such a well-respected group of life sciences investors who share our vision of transforming the way drugs are created,” said Sean McClain, founder and CEO of AbSci. “As we unlock access to novel biologies and therapeutic modalities, and work with our partners to create exciting new medicines, we are continuing to innovate and expand the scope of what we can accomplish and the impact we can have to improve human health.”

Eli Casdin, Chief Investment Officer and Founder of Casdin Capital, commented, “In the short time since the Series E, AbSci has made tremendous progress, advancing drug discovery technologies, acquiring Denovium, a state-of-the-art deep learning platform for protein engineering, and announcing partnerships with both Merck and Astellas. We look forward to seeing AbSci continue to execute on its vision.”

Proceeds will support AbSci’s continued growth, including research and development activities and other strategic investments. Key areas of focus are integration and training of the Denovium EngineTM deep learning artificial intelligence platform AbSci acquired in January 2021, and ongoing expansion of core discovery capabilities including non-standard amino acid technologies.

“We believe that AbSci has a truly differentiated approach, which includes a fully integrated technology for simultaneously discovering new biologics and the cell lines to manufacture them,” said Dan Sundheim, Chief Investment Officer and Founder of D1 Capital Partners. “We are excited to support the company as it advances programs with partners and participates in creating better medicines for patients.”

About AbSci

AbSci is a leading synthetic biology company that translates ideas into drugs with a revolutionary platform technology that reinvents the biopharmaceutical drug discovery process. Our patented SoluPro® E. coli expression system and Protein Printing™ platform, informed by our deep learning Denovium Engine™, enable simultaneous creation of novel biotherapeutic drugs and the cell lines to manufacture them in a single efficient process. In one workflow, we select cell lines producing drug candidates with optimal target potency and affinity as well as high-titer expression. Starting with a known drug sequence or with a target for de novo discovery, our approach dramatically reduces biopharma discovery and development timelines from years to weeks by generating a GMP-ready manufacturing cell line for each asset. We specialize in next-generation biologics built on complex protein scaffolds, which have proven challenging for others to produce. With more than a dozen partnerships in place with top pharma and industry leaders, our collaborations include projects for drugs and drug candidates that range across multiple protein types and therapeutic functionality. For more information, please visit https://www.absci.com.

VANCOUVER, Wash., – February 22, 2021 – AbSci, a pioneering synthetic biology company that unifies biologic drug discovery and development processes, today announced a strategic equity investment by Merck Global Health Innovation Fund (Merck GHI) and potential discovery collaborations with Merck Research Laboratories.

AbSci founder and CEO Sean McClain said, “It has been terrific to work with Merck on many levels. We are pleased to be able to add value and bring solutions to tough problems. With the success of our initial projects, as well as this investment from Merck GHI, we have set in place a foundation upon which to build out a broad and mutually beneficial partnership with Merck. Everyone we have worked with at Merck shares the goal of helping the most patients with the best medicines as quickly as possible.”

“AbSci falls into a special investment allocation towards what we see as ‘Next Horizon’ technologies that have the potential to disrupt the biopharmaceutical industry,” said Prem Tumkosit, Managing Director of Merck GHI. “AbSci’s technologies may enable discovery and development of exciting new biotherapeutics that could meaningfully impact human health in the years to come.”

This partnership aligns with AbSci’s research and development activities. Key areas of focus are integration and training of the Denovium Engine deep learning artificial intelligence platform AbSci acquired in January 2021, and ongoing expansion of core discovery capabilities including non-standard amino acid technologies. AbSci’s Protein PrintingTM platform technology enables de novo biologic drug creation in a matter of weeks. It is scaffold-agnostic; by screening for initial hits in the desired full-length scaffold format, and in the cell line that will be used for manufacturing, AbSci dramatically accelerates preclinical timelines and offers avenues to create designer next-generation biologics that would not otherwise be possible.

About Merck Global Health Innovation Fund

Merck Global Health Innovation Fund (Merck GHI) is evolving corporate healthcare venture capital globally by utilizing their healthcare ecosystem strategy. This investment strategy connects innovative companies with complementary technologies to develop integrated healthcare solutions. Merck GHI has $500M under management and provides growth capital to emerging healthcare technology companies worldwide while leveraging the vast R&D-based, global resources of Merck. With a vision that data will be the currency in healthcare, Merck GHI invests broadly in digital health. Merck GHI invests in platform companies with proven technologies or business models where Merck’s expertise and perspectives can accelerate revenue growth and enhance value creation.  Since late 2010, Merck GHI has made over 50 investments in Digital Health companies. www.merckghifund.com

About AbSci

AbSci is a leading synthetic biology company that translates ideas into drugs with a revolutionary platform technology that reinvents the biopharmaceutical drug discovery process. Our patented SoluPro® E. coli expression system and Protein Printing™ platform, informed by our deep learning Denovium Engine™, enable simultaneous creation of novel biotherapeutic drugs and the cell lines to manufacture them in a single efficient process. In one workflow, we select cell lines producing drug candidates with optimal target potency and affinity as well as high-titer expression. Starting with a known drug sequence or with a target for de novo discovery, our approach dramatically reduces biopharma discovery and development timelines from years to weeks by generating a GMP-ready manufacturing cell line for each asset. We specialize in next-generation biologics built on complex protein scaffolds, which have proven challenging for others to produce. With more than a dozen partnerships in place with top pharma and industry leaders, our collaborations include projects for drugs and drug candidates that range across multiple protein types and therapeutic functionality. For more information, please visit https://www.absci.com.

-Second molecule addressed under the collaboration agreement, first to exploit AbSci discovery technologies-

 VANCOUVER, Wash., February 3, 2021 /PRNewswire/ — AbSci, a pioneering synthetic biology company enabling drug discovery and biomanufacturing of next-generation biotherapeutics, today announced that it has partnered with Xyphos Biosciences, an Astellas Company, to screen and identify a variant of Xyphos’ MicAbody™ lead candidate for optimal manufacturing cell line development. The MicAbody is a bispecific antibody-like adaptor molecule critical for Xyphos’ program in immuno-oncology. The agreement between the companies calls for AbSci to employ its Protein PrintingTM technology to inform selection of optimal variant MicAbody candidates and a custom E. coli SoluPro® production strain for further potential development and cGMP manufacturing.

AbSci founder & CEO Sean McClain commented, “We are pleased to expand our relationship with Xyphos to include AbSci’s discovery capabilities, and we look forward to continuing our partnership as Xyphos and Astellas advance development of molecules manufactured using our Protein Printing platform.”

Financial terms of the agreement were not disclosed.

About AbSci

AbSci is a leading synthetic biology company that translates ideas into drugs with a revolutionary platform technology that reinvents the biopharmaceutical drug discovery process. Our patented SoluPro® E. coli expression system and Protein Printing™ platform, informed by our deep learning Denovium Engine™, enable simultaneous creation of novel biotherapeutic drugs and the cell lines to manufacture them in a single efficient process. In one workflow, we select cell lines producing drug candidates with optimal target potency and affinity as well as high-titer expression. Starting with a known drug sequence or with a target for novel drug discovery, our approach dramatically reduces biopharma discovery and development timelines from years to weeks by generating a GMP-ready manufacturing cell line for each asset. We specialize in next-generation biologics built on complex protein scaffolds, which have proven challenging for others to produce. With more than a dozen partnerships in place with top pharma and industry leaders, our collaborations include projects for 28 drugs and drug candidates that range across multiple protein types and therapeutic functionality. For more information, please visit https://www.absci.com.

About Xyphos Biosciences, Inc., an Astellas Company.

Xyphos Biosciences, Inc., located at South San Francisco, Calif., is a wholly owned subsidiary of Astellas featuring ACCELTM technology, a technology platform for CAR (chimeric antigen receptor) – immune cell therapy. ACCELTM technology is based on the fusion of receptor-expressing immune cells such as natural killer (NK) cells and T cells (convertibleCAR® cells) with antibodies that recognize cancer antigens, the target of attack. The technology is based on the administration of an antibody-ligand fusion protein (MicAbody), which is a fusion of an antibody and a ligand protein. By replacing or using multiple MicAbodies according to the characteristics of the cancer cells to be attacked, convertibleCAR® cells can recognize different cancer antigens or multiple cancer antigens and attack various cancer cells. Xyphos Biosciences was launched in 2017, and the Company was acquired by Astellas Pharma in December of 2019. For more information about the Company, please visit www.xyphosinc.com.

About Astellas

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are promoting the Focus Area Approach that is designed to identify opportunities for the continuous creation of new drugs to address diseases with high unmet medical needs by focusing on Biology and Modality. Furthermore, we are also looking beyond our foundational Rx focus to create Rx+® healthcare solutions that combine our expertise and knowledge with cutting-edge technology in different fields of external partners. Through these efforts, Astellas stands on the forefront of healthcare change to turn innovative science into value for patients. For more information, please visit our website at https://www.astellas.com/en.

AbSci Contact
Kate Corcoran, Ph.D.
[email protected]
360-949-1041

Integration of Denovium Engine™ with AbSci’s Protein Printing™ Platform to enable creation of novel biotherapeutics and manufacturing cell lines with the click of a button

 Vancouver, Wash., January 12, 2021 – AbSci, a leading synthetic biology company enabling drug discovery and biomanufacturing of next-generation biotherapeutics, today announced the acquisition of Denovium, Inc., an artificial intelligence (AI) deep learning company. AbSci will integrate the Denovium Engine into its drug discovery and manufacturing cell line development capabilities and expects to realize near term synergies using AI deep learning to better predict relevant variants and cell line characteristics for each new project. With continued application and further training of the Denovium Engine, AbSci’s vision is to make in silico biologic drug discovery and cell line development a reality. This will enable next-generation therapies to make it to market at unprecedented speeds. Terms of the acquisition are not being disclosed.

“This acquisition represents the perfect synergy of groundbreaking synthetic biology and cutting-edge deep learning AI to create in silico predictive protein drug design and cell line development capabilities with the potential to completely change the paradigm of biopharmaceutical discovery and development,” said Sean McClain, founder and CEO of AbSci. “Incorporating deep learning will allow us to explore all possible protein sequences in silico, including those that Nature’s evolutionary trajectory has yet to consider, to identify drug candidates with optimal therapeutic properties and manufacturability. Combining that design power with our proprietary data from our Protein Printing platform, AbSci can create a new gold standard for drug discovery and cell line development for next-generation biologics while at the same time allowing for creation of novel biologies previously unattainable.”

The Denovium Engine is a multidimensional deep learning model built to interpret, categorize, predict, and evolve function and behavior of proteins. The platform incorporates far more than sequence and structure relationships, having been trained on functional data from more than 100 million proteins and across over 700,000 descriptive parameters. AbSci intends to further train the Denovium Engine on its proprietary internally-generated multidimensional protein characterization datasets that include elements of protein functionality, expression, and manufacturability.

“Training the Denovium Engine on the volumes of high-quality protein function and manufacturability data being generated by AbSci’s Protein Printing platform allows our platform to reach its full potential of de novo design of manufacturable proteins having desirable functionalities,” said Toby Richardson, Ph.D., founder and CEO of Denovium. “We expect that the platform will be able to design proteins by predicting not only the optimal sequence for each therapeutic candidate, but also the conditions for manufacturing, to enable production of therapeutic proteins that were previously not possible.”

About Denovium Inc.

Denovium is an artificial intelligence company pioneering novel AI methods to accelerate innovation in biopharma. Founded by genomics and computer science experts, Denovium is building an artificial intelligence engine (Denovium Engine™) capable of interpreting disparate biological data types to answer biology’s toughest questions. Denovium is partnering with leading biotech and pharma companies in specific areas of focus including gene discovery, protein engineering and genomic medicine.

About AbSci

AbSci is a leading synthetic biology company that translates ideas into drugs with a revolutionary platform technology that reinvents the biopharmaceutical drug discovery process. Our patented SoluPro® E. coli expression system and Protein Printing™ platform enable simultaneous creation of novel biotherapeutic drugs and the cell lines to manufacture them in a single efficient process. In one workflow, we select cell lines producing drug candidates with optimal target potency and affinity as well as high-titer expression. Starting with a known drug sequence or with a target for novel drug discovery, our approach dramatically reduces biopharma discovery and development timelines from years to weeks by generating a GMP-ready manufacturing cell line for each asset. We specialize in next-generation biologics built on complex protein scaffolds, which have proven challenging for others to produce. With more than a dozen partnerships in place with top pharma and industry leaders, our collaborations include projects for 28 drugs and drug candidates that range across multiple protein types and therapeutic functionality. For more information, please visit https://www.absci.com.

# # #

Media Contact
Heidi Chokeir, Ph.D.
Canale Communications
[email protected]
619-203-5391

Investor Contact
Kate Corcoran, Ph.D.
[email protected]
360-949-1041

VANCOUVER, Wash.Jan. 7, 2021 /PRNewswire/ — AbSci, a leading synthetic biology company enabling drug discovery and biomanufacturing of next generation biotherapeutics, today announced that Sean McClain, Founder and CEO, will present virtually at the 39th Annual J.P. Morgan Healthcare Conference on Tuesday, January 12, 2021 at 7:25 a.m. PT / 10:25 a.m. ET.

About AbSci

AbSci is ushering in a new era of biopharmaceutical discovery and manufacturing technologies, designing and programming E. coli bacteria to produce challenging biologics at commercial scale. AbSci’s patented SoluPro(R) expression platform enables rapid and robust production of complex proteins, ranging from antibodies, antibody fragments, enzymes, hormones and peptides, to emerging novel classes of biotherapeutics. AbSci’s discovery engine and Protein Printing™ technology offer unprecedented efficiencies by enabling simultaneous optimization of drug candidate potency and affinity combined with high-titer cell line development. The system increases discovery throughput, accelerates commercial process development, reduces manufacturing costs, and increases plant capacity for biopharmaceutical partners, enabling novel biologics to advance to market and creating a new gold standard in biotherapeutic discovery and production. For more information, please visit https://www.absci.com.

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